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August 16, 2007

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Paul Flynn

The news about ibuprofen was published about two years ago and the risk, as you say, is less than the Cox2s. Unfortunately recent evidence on Seroxat is that GSK has suppressed the results of trials that had adverse side effects and published only those with positive results.

valleylad

I don't have a reference to hand to check, but I seem to remember that the increased risk from ibuprofen whilst large as a percentage was small in number. In other words if drug X increased your risk of a heart attack from 1 in 1,000,000 to 2 in 1,000,000 that is a 100% increase, but probably not anything to worry about.

As to the dangers from big pharma, as usual Ben Goldacre had a lot of sensible suggestions in his Staurday Guardian column (it's also on his website badscience.net under more worse trials). Obviously with politicians and civil servants involved it is highly unlikely anything so sensible would ever happen ...

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